Book

Description

My research work was mainly focus on simultaneous analysis of five most potent antihypertensive drug with new generation UPLC technique. The purpose of this study was to develop and validate an isocratic mobile phase containing RP-UPLC technique for the simultaneous assessment of Guanfacine hydrochloride, Sildenafil, Irbesartan, Losartan potassium and Indapamide in dosage form with the simplest LC method. For diverse dose forms of medications, the pharmaceutical industries used time-consuming methods and varied mobile phases. However, the current method only required one mobile phase and 3.5 minutes to determine all five medicines at the same time. As a result, time and money spent changing mobile phases could be saved. Also work contain RP-HPLC method development of anticoagulant Revaroxaban with technology transfer on UPLC. The developed HPLC method was stability indicating with mainly focus on stress degradation study. This book can be used for detection and quantification of said drugs in routine analysis, special analysis and in-process control as well Quality Control laboratory in pharmaceutical Industries. Researchers can also use this method as a reference for further study.